HLA Class I and Class II Alleles and Haplotypes Confirm the Berber Origin of the Present Day Tunisian Population
Identifieur interne : 000042 ( Main/Exploration ); précédent : 000041; suivant : 000043HLA Class I and Class II Alleles and Haplotypes Confirm the Berber Origin of the Present Day Tunisian Population
Auteurs : Abdelhafidh Hajjej [Tunisie] ; Wassim Y. Almawi [Bahreïn] ; Lasmar Hattab [Tunisie] ; Amel El-Gaaied [Tunisie] ; Slama Hmida [Tunisie]Source :
- PLoS ONE [ 1932-6203 ] ; 2015.
Abstract
In view of its distinct geographical location and relatively small area, Tunisia witnessed the presence of many civilizations and ethnic groups throughout history, thereby questioning the origin of present-day Tunisian population. We investigated HLA class I and class II gene profiles in Tunisians, and compared this profile with those of Mediterranean and Sub-Sahara African populations. A total of 376 unrelated Tunisian individuals of both genders were genotyped for HLA class I (A, B) and class II (DRB1, DQB1), using reverse dot-blot hybridization (PCR-SSO) method. Statistical analysis was performed using Arlequin software. Phylogenetic trees were constructed by DISPAN software, and correspondence analysis was carried out by VISTA software. One hundred fifty-three HLA alleles were identified in the studied sample, which comprised 41, 50, 40 and 22 alleles at HLA-A,-B,-DRB1 and -DQB1 loci, respectively. The most frequent alleles were HLA-A*02:01 (16.76%), HLA-B*44:02/03 (17.82%), HLA-DRB1*07:01 (19.02%), and HLA-DQB1*03:01 (17.95%). Four-locus haplotype analysis identified HLA-A*02:01-B*50:01-DRB1*07:01-DQB1*02:02 (2.2%) as the common haplotype in Tunisians. Compared to other nearby populations, Tunisians appear to be genetically related to Western Mediterranean population, in particular North Africans and Berbers. In conclusion, HLA genotype results indicate that Tunisians are related to present-day North Africans, Berbers and to Iberians, but not to Eastern Arabs (Palestinians, Jordanians and Lebanese). This suggests that the genetic contribution of Arab invasion of 7th-11th century A.D. had little impact of the North African gene pool.
Url:
DOI: 10.1371/journal.pone.0136909
PubMed: 26317228
PubMed Central: 4552629
Affiliations:
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Almawi</name><affiliation wicri:level="1"><nlm:aff id="aff002"><addr-line>Department of Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain</addr-line></nlm:aff><country xml:lang="fr">Bahreïn</country><wicri:regionArea>Department of Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, Manama</wicri:regionArea><wicri:noRegion>Manama</wicri:noRegion></affiliation></author><author><name sortKey="Hattab, Lasmar" sort="Hattab, Lasmar" uniqKey="Hattab L" first="Lasmar" last="Hattab">Lasmar Hattab</name><affiliation wicri:level="1"><nlm:aff id="aff003"><addr-line>Department of Medical Analysis, Regional Hospital of Gabes, Gabes, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Medical Analysis, Regional Hospital of Gabes, Gabes</wicri:regionArea><wicri:noRegion>Gabes</wicri:noRegion></affiliation></author><author><name sortKey="El Gaaied, Amel" sort="El Gaaied, Amel" uniqKey="El Gaaied A" first="Amel" last="El-Gaaied">Amel El-Gaaied</name><affiliation wicri:level="3"><nlm:aff id="aff004"><addr-line>Laboratory of Immunogenetics, Department of Biology, University of Tunis – El-Manar, Tunis, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Immunogenetics, Department of Biology, University of Tunis – El-Manar, Tunis</wicri:regionArea><placeName><settlement type="city">Tunis</settlement><region nuts="2">Gouvernorat de Tunis</region></placeName></affiliation></author><author><name sortKey="Hmida, Slama" sort="Hmida, Slama" uniqKey="Hmida S" first="Slama" last="Hmida">Slama Hmida</name><affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Department of Immunogenetics, National Blood Transfusion Center, Tunis, Tunisia</addr-line></nlm:aff><country xml:lang="fr">Tunisie</country><wicri:regionArea>Department of Immunogenetics, National Blood Transfusion Center, Tunis</wicri:regionArea><placeName><settlement type="city">Tunis</settlement><region nuts="2">Gouvernorat de Tunis</region></placeName></affiliation></author></analytic><series><title level="j">PLoS ONE</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In view of its distinct geographical location and relatively small area, Tunisia witnessed the presence of many civilizations and ethnic groups throughout history, thereby questioning the origin of present-day Tunisian population. We investigated HLA class I and class II gene profiles in Tunisians, and compared this profile with those of Mediterranean and Sub-Sahara African populations. A total of 376 unrelated Tunisian individuals of both genders were genotyped for HLA class I (A, B) and class II (DRB1, DQB1), using reverse dot-blot hybridization (PCR-SSO) method. Statistical analysis was performed using Arlequin software. Phylogenetic trees were constructed by DISPAN software, and correspondence analysis was carried out by VISTA software. One hundred fifty-three HLA alleles were identified in the studied sample, which comprised 41, 50, 40 and 22 alleles at HLA-A,-B,-DRB1 and -DQB1 loci, respectively. The most frequent alleles were HLA-A*02:01 (16.76%), HLA-B*44:02/03 (17.82%), HLA-DRB1*07:01 (19.02%), and HLA-DQB1*03:01 (17.95%). Four-locus haplotype analysis identified HLA-A*02:01-B*50:01-DRB1*07:01-DQB1*02:02 (2.2%) as the common haplotype in Tunisians. Compared to other nearby populations, Tunisians appear to be genetically related to Western Mediterranean population, in particular North Africans and Berbers. In conclusion, HLA genotype results indicate that Tunisians are related to present-day North Africans, Berbers and to Iberians, but not to Eastern Arabs (Palestinians, Jordanians and Lebanese). This suggests that the genetic contribution of Arab invasion of 7<sup>th</sup>-11<sup>th</sup> century A.D. had little impact of the North African gene pool.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Mungall, Aj" uniqKey="Mungall A">AJ Mungall</name></author><author><name sortKey="Palmer, Sa" uniqKey="Palmer S">SA Palmer</name></author><author><name sortKey="Sims, Sk" uniqKey="Sims S">SK Sims</name></author><author><name sortKey="Edwards, Ca" uniqKey="Edwards C">CA Edwards</name></author><author><name sortKey="Ashurst, Jl" uniqKey="Ashurst J">JL Ashurst</name></author><author><name sortKey="Wilming, L" uniqKey="Wilming L">L Wilming</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sanchez Mazas, A" uniqKey="Sanchez Mazas A">A Sanchez-Mazas</name></author><author><name sortKey="Fernandez Vi A, M" uniqKey="Fernandez Vi A M">M Fernandez-Viña</name></author><author><name sortKey="Middleton, D" 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Rodd</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Lewis, B" uniqKey="Lewis B">B Lewis</name></author><author><name sortKey="Ayalon, David" uniqKey="Ayalon D">David Ayalon</name></author><author><name sortKey="Sharon, Moshe" uniqKey="Sharon M">Moshe Sharon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Camps, G" uniqKey="Camps G">G Camps</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Abun Nasr, Jm" uniqKey="Abun Nasr J">JM Abun-Nasr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fischer, T" uniqKey="Fischer T">T Fischer</name></author><author><name sortKey="Mill" uniqKey="Mill">Mill</name></author><author><name sortKey="Hugh, Robert" uniqKey="Hugh R">Robert Hugh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sams, J" uniqKey="Sams J">J Samsó</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Bahreïn</li><li>Tunisie</li></country><region><li>Gouvernorat de Tunis</li></region><settlement><li>Tunis</li></settlement></list><tree><country name="Tunisie"><region name="Gouvernorat de Tunis"><name sortKey="Hajjej, Abdelhafidh" sort="Hajjej, Abdelhafidh" uniqKey="Hajjej A" first="Abdelhafidh" last="Hajjej">Abdelhafidh Hajjej</name></region><name sortKey="El Gaaied, Amel" sort="El Gaaied, Amel" uniqKey="El Gaaied A" first="Amel" last="El-Gaaied">Amel El-Gaaied</name><name sortKey="Hattab, Lasmar" sort="Hattab, Lasmar" uniqKey="Hattab L" first="Lasmar" last="Hattab">Lasmar Hattab</name><name sortKey="Hmida, Slama" sort="Hmida, Slama" uniqKey="Hmida S" first="Slama" last="Hmida">Slama Hmida</name></country><country name="Bahreïn"><noRegion><name sortKey="Almawi, Wassim Y" sort="Almawi, Wassim Y" uniqKey="Almawi W" first="Wassim Y." last="Almawi">Wassim Y. Almawi</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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